In study after study, Mitragynine is called out as the most prevalent and potent alkaloid in the kratom leaf’s arsenal. But what do we really know about this naturally occurring plant compound and how it works? First identified over a hundred years ago, we are still gathering information about how this substance interacts with the human body. To get the most out of your kratom experience, it’s valuable to peek under the hood to get a better sense of what gives the herbal remedy its famous power. Here’s a summary of what we know so far about how these alkaloids function.
Mitragynine, known by the chemical name C23H30N2O4, comprises at least .5 percent of the leaves of Mitragyna Speciosa, also known as kratom. That may not sound like a huge number, but it is dominant alkaloid present among a list of at least 40. Similar to some Yohimbe alkaloids, the compound works by binding to alpha-adrenergic receptors in the cells of the body. The simulation of these postsynaptic adrenoreceptors is the heart of most effects we in turn feel after consuming some form of the plant.
Doses and Effects
How does that translate into English for the average user? Mitragynine acts as a powerful stimulant. It is theorized to possess both calming and energizing effects, which vary based on dosage. Common effects reported from kratom alkaloid ingestion include intense concentration and focus, natural feeling physical energy, relief from symptoms of anxiety and depression, stress relief, muscle relaxation, regulation of sleep schedules, boosted immune response, increased sexual drive and longer sexual performance, emotional feelings of euphoria, joy, and optimism. It is not known how many of these effects are solely attributable to mitragynine isolate. Many believe it is the synergistic interaction with all of the plant alkaloids present in kratom which deliver these effects.
Dosage: It has been well-documented that lower dosage amounts of kratom products produce more stimulating, energizing effects, while larger doses are responsible for more relaxing and even sedating effects in the body.
Excellent Long Term Health Benefits
There do appear to be many significant health benefits associated with the use of mitragynine extract. As kratom use has only recently begin to pick up major popularity and acceptance in the West, adequate research studies are still getting underway. However, many early studies have noted correlations between kratom ingestion and serious health benefits, like anti-bacterial and anti-viral properties. The longer we put off funding serious scientific research studies of kratom alkaloids, the longer sufferers of major ailments like these could be without a natural solution.
Mitragynine Toxicity and Side Effects
While side effects are in general reported to be mild and not long lasting, some users will experience light adverse effects to doses of mitragynine that are too large for their systems to successfully process in one session. These symptoms include many sensations associated with the stomach and digestion, such as nausea, loss of appetite, and constipation. Other side effects can include dry mouth, trouble sleeping on a normal schedule, and brain fog.
How To Boost Alkaloid Intake
To receive the full health benefits of kratom and its health-boosting alkaloids, many users look for ways to increase the potency of the products they consume. In addition to finding a strain and dosage that works for the individual, newer techniques of extraction have recently come into vogue.
An extraction is the process of boiling down kratom leaves to create ultra-potent resins, powders, and tinctures that are extremely dense with alkaloids. By adding these extracts to conventional powders, or taking them in smaller doses on their own, users are able to supercharge the intensity of health benefits that kratom leaves can bring. Products like this 15x Extract are a powerful aid at both the prevention or healing stage for a variety of health issues. It is also now possible to buy Mitragynine as a pure alkaloid on its own, though we do not recommend using these products due to increased risk of tolerance and side effects.
Our understanding of mitragynine is still developing day by day. For now, we know it is a vital piece of the puzzle, and fuels a significant portion of kratom’s legendary effects for mind and body. By lobbying for increased research funding and global legal acceptance, we may be paving the way for future medicinal applications of this powerful alkaloid that we have only just begun to dream of.